Ardelyx rolls out positive PhIII IBS-C data on tenapanor as rivals prep for a showdown, but shares crater
Two days ago it was Synergy Pharma’s turn to tout positive Phase III data on its drug Trulance for irritable bowel syndrome with constipation. Today, rival Ardelyx $ARDX is stepping up with the first of its two Phase III readouts on tenapanor as the newcomers look to challenge Ironwood’s market-leading therapy. And at first blush, investors weren’t impressed.
All but one of the key data points were all positive. In the primary goal, observing the impact of their drug in 6 of 12 weeks of therapy, 27% in the tenapanor arm scored a complete response on a significant 30% or greater reduction in abdominal pain and at least one added complete bowel movement from baseline — compared to 18.7% in the placebo group.
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