In­cyte hires Janssen ex­ec as CSO Hu­ber moves to Third Rock; Syn­thorx set terms for $100M IPO

→ Ahead of an FDA de­ci­sion on its key drug Jakafi’s use in graft vs. host dis­ease, In­cyte $IN­CY has lost its chief sci­en­tif­ic of­fi­cer Reid Hu­ber to promi­nent health­care ven­ture firm Third Rock, but is bring­ing in Janssen’s Dashyant Dhanak to fill the gap.

Dhanak will need to get his act to­geth­er be­fore the up­com­ing Amer­i­can So­ci­ety of Hema­tol­ogy (ASH) con­fer­ence slat­ed for this week­end, where In­cyte is mak­ing mul­ti­ple da­ta pre­sen­ta­tions, in­clud­ing up­dat­ed da­ta for Jakafi in com­bi­na­tion with its PI3K-delta in­hibitor IN­CB50465 in pa­tients with myelofi­bro­sis. This com­bi­na­tion is ex­pect­ed to play a crit­i­cal role in ex­pand­ing the Jakafi fran­chise in myelo­pro­lif­er­a­tive neo­plasms, a group of rare dis­or­ders of the bone mar­row that cause an in­crease in the num­ber of blood cells.

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