In a rare block­buster per­for­mance for As­traZeneca, Tagris­so comes through on lung can­cer PhI­II

For a Big Phar­ma com­pa­ny that of­ten gets things wrong, Tagris­so has been As­traZeneca’s ace in the hole. Sped through the clin­ic to a first ap­proval in an as­ton­ish­ing two years, it was al­ready on the mar­ket when Clo­vis’ ri­val im­plod­ed on ar­rival at the FDA.

To­day, the phar­ma gi­ant is pulling back the veil off of new da­ta demon­strat­ing a 5.7-month im­prove­ment in pro­gres­sion-free sur­vival of non-small cell lung can­cer among pa­tients with an epi­der­mal growth fac­tor re­cep­tor (EGFR) T790M mu­ta­tion com­pared to plat­inum-based dou­blet chemother­a­py (10.1 months vs 4.4 months). And the PFS spread sig­nif­i­cant­ly fa­vored Tagris­so among the one-third of pa­tients with CNS metas­tases.

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