No­var­tis of­floads a late-stage PI3Kẟ rare dis­ease pro­gram in a dis­count deal

Look­ing to build on their fran­chise HAE drug Ru­con­est, Dutch biotech Pharm­ing has snapped up a late-stage rare dis­ease drug from No­var­tis for a mod­est up­front of on­ly $20 mil­lion.

The phar­ma gi­ant is sell­ing glob­al rights to CDZ173, a small mol­e­cule phos­pho­inosi­tide 3-ki­nase delta (PI3Kẟ) in­hibitor in de­vel­op­ment for Ac­ti­vat­ed Phos­pho­inosi­tide 3-ki­nase Delta Syn­drome —or APDS. And No­var­tis will com­plete the Phase II/III reg­is­tra­tion study as well as an on­go­ing open-la­bel ex­pan­sion study for Pharm­ing.

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