Promising or inconclusive? Gilead fields PhII GS-4997 data, triggering more pushback on NASH claims
Gilead posted a detailed snapshot of Phase II efficacy data for GS-4997, now known as selonsertib, for NASH and liver fibrosis, triggering a mixed response of enthusiasm and some clear skepticism from the analysts watching this late-stage drug, some of whom got their first crack in when Gilead outlined the top line data from this study in October.
The numbers were detailed for selonsertib alone, in combination with simtuzumab or in simtuzumab alone. And investigators had a mixed bag of results underscoring drug activity, ranging from the 43% of patients taking selonsertib seeing an improvement in fibrosis compared to the 20% in the simtuzumab arm to the 20% in the selonsertib arm experiencing a minimum 15% reduction in liver stiffness to the 32% in the combo group and none taking simtuzumab alone.
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