R&D

RIP tanezumab? Eli Lilly, Pfizer spotlight alarming safety data for NGF pain drug in PhIII

Nearly a decade after the anti-NGF class of pain drugs was crushed by safety issues and then began a long, agonizingly slow return to late-stage testing, it may all be over soon. Pfizer and Eli Lilly posted a set of longterm outcomes from a Phase III study of tanezumab, and once they got a glimpse of the data analysts immediately started to pen last rites for the drug.

A rival therapy from Regeneron and Teva isn’t being given good odds of survival.

There were mixed efficacy results for the Pfizer/Lilly program, with only the high dose achieving a statistically significant improvement for pain and physical function over NSAIDS. And the pain data were alarming, reflecting earlier concerns spotlighted by researchers.


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VP Oncology Biology
Skyhawk Therapeutics Waltham, MA
Associate Director CMC
Elektroki Boston, MA
Director Process Development
Elektroki Boston, MA
Research Scientist - Immunology
Recursion Pharmaceuticals Salt Lake City, UT

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