How CAMP4 maps transcription [CAMP4TX]

Tar­get­ing the BF­Ps of the CNS, Bio­gen li­cens­es map of ge­net­ic neigh­bor­hoods in the brain

Search­ing for new meth­ods of at­tack­ing se­ri­ous cen­tral ner­vous sys­tem dis­eases, Bio­gen has signed a deal that could be run in­to the hun­dreds of mil­lions of dol­lars to es­sen­tial­ly li­cense a tran­scrip­tion­al map of the brain and scan it for new drug tar­gets.

The part­ner­ship, worth $15 mil­lion up­front and far more in mile­stones, is with a new bioin­for­mat­ics start­up called CAMP4 Ther­a­peu­tics.  Found­ed in 2018 year by the White­head In­sti­tute’s Richard Young and Har­vard Med­ical School’s Leonard Zon, CAMP4 takes genes con­sid­ered af­fil­i­at­ed with a dis­ease and maps out the var­i­ous ways cells ex­press those genes and turn them on or off.  They then take that map and – in the bi­o­log­i­cal equiv­a­lent of stretch­ing a war map across a ta­ble in a bunker —  mark up all the dif­fer­ent meth­ods of at­tack.

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