While we wait for NASH da­ta, Gen­fit re­ports pos­i­tive elafi­bra­nor da­ta in PBC pa­tients

As a late-stage da­ta show­down from NASH drug de­vel­op­ers Gilead $GILD, In­ter­cept $ICPT and France’s Gen­fit (Eu­roNext: $GN­FT) looms, the Lille-based drug de­vel­op­er on Thurs­day re­port­ed pos­i­tive phase II da­ta on its drug elafi­bra­nor in pa­tients with pri­ma­ry bil­iary cholan­gi­tis (PBC), a rare and pro­gres­sive liv­er dis­ease.

The 12-week phase II tri­al test­ed two dos­es of the dual PPARα/δ ag­o­nist elafi­bra­nor against a place­bo in PBC pa­tients that did not de­rive ad­e­quate ben­e­fit from stan­dard treat­ment, ur­sodeoxy­cholic acid. Both dos­es of the once-dai­ly treat­ment con­ferred a sta­tis­ti­cal­ly sig­nif­i­cant de­crease in serum al­ka­line phos­phatase (ALP) lev­els. High ALP typ­i­cal­ly in­di­cates a liv­er in dis­tress.

Jean-François Mouney, Gen­fit CEO

Da­ta showed a fall of 48% for pa­tients who got the 80 mg dose (p<0.001), and drop of 41% in those who re­ceived the 120 mg dose (p<0.001), while those on place­bo saw their ALP lev­els edge 3% high­er. Along­side, the drug met the com­pos­ite sec­ondary end­point — which has been pre­vi­ous­ly used for reg­u­la­to­ry ap­proval — and in­duced im­prove­ment in oth­er PBC mark­ers, the com­pa­ny said, adding that its drug had been well tol­er­at­ed.

That’s enough for Gen­fit chief Jean-François Mouney to de­clare the drug ready for late-stage de­vel­op­ment in PBC, not­ing, “the strength of ev­i­dence on the sur­ro­gate end­point for reg­is­tra­tion as well as the po­ten­tial ben­e­fits on itch­ing qual­i­fy the pro­gram to rapid­ly ad­vance.”

Ve­limir Luket­ic, a re­searcher from the Vir­ginia Com­mon­wealth Uni­ver­si­ty School of Med­i­cine added: “A sub­stan­tial num­ber of pa­tients do not ben­e­fit from the cur­rent­ly avail­able ther­a­pies – UD­CA or OCA (Ocali­va) – ei­ther be­cause of lack of re­sponse or in­tol­er­a­ble side ef­fects. The da­ta emerg­ing from this clin­i­cal tri­al are very im­pres­sive, par­tic­u­lar­ly the sub­stan­tial re­duc­tion in ALP in just 12 weeks.”

Phase III da­ta on elafi­bra­nor for NASH — in what is ex­pect­ed to be a far more lu­cra­tive mar­ket — is ex­pect­ed in 2019. The bio­phar­ma In­ter­cept, whose NASH drug-in-de­vel­op­ment is al­ready ap­proved for PBC un­der the name Ocali­va, has brought in near­ly $125 mil­lion in sales in the first nine months of this year, while CymaBay’s $CBAY PPAR ag­o­nist se­ladel­par en­tered late-stage de­vel­op­ment in Oc­to­ber for PBC.

Last month, Gen­fit an­nounced plans to list it­self in the Unit­ed States.

Com­mu­ni­cat­ing the val­ue of pre­ci­sion med­i­cine

By Natasha Cowan, Content Marketing Manager at Blue Latitude Health.
Many stakeholders are confused by novel precision medicines, including patients and healthcare professionals. So, how can industry help them to navigate this complexity?

Precision medicine represents a new paradigm in healthcare. It embodies the shift from treating many patients with the same therapy, to having the tools to identify the best treatment for every patient.

Mer­ck buys a fledg­ling neu­rode­gen­er­a­tive biotech spawned by an old GSK dis­cov­ery al­liance. What’s up with that?

Avalon Ventures chief Jay Lichter has a well-known yen for drug development programs picked up in academia. And what he found in Haoxing Xu’s lab at the University of Michigan pricked his interest enough to launch one of his umbrella biotechs in San Diego.
Xu’s work laid the foundation for Avalon to launch Calporta, which has been working on finding small molecule agonists of TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) for lysosomal storage disorders. And that pathway, they believe, points to new approaches on major market neurodegenerative diseases like Parkinson’s, ALS and Alzheimer’s.

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In­vestors could emerge from Neil Wood­ford de­ba­cle with £1B loss, in­ter­nal analy­sis re­veals

When Link Fund Solutions announced that it is closing Woodford Equity Income Fund permanently and kicking out Neil Woodford, it was implied that investors probably won’t get back everything they entrusted to the fund manager. But nobody knew just how much they would lose.

An internal analysis commissioned by Link suggested that the collective loss could amount to £1 billion — out of a fund last valued at £3.1 billion — Citywire has revealed.

GSK's asth­ma bi­o­log­ic Nu­cala scores in rare blood dis­or­der study

GlaxoSmithKline’s asthma drug Nucala, which received a resounding FDA rejection for use in chronic obstructive pulmonary disease (COPD) last year, has shown promise in a rare blood disorder.

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Spe­cial re­port: Twen­ty ex­tra­or­di­nary women in bio­phar­ma R&D who worked their way to the top

What differentiates a woman leader in biopharma R&D from a man?

Not much, except there are fewer of them in senior posts. Data suggest women are not more risk-averse, family-oriented or less confident than their male counterparts — indeed the differences between the two sexes are negligible. But a glance at the top R&D positions in Big Pharma leaves little doubt that upward migration in the executive ranks of biopharma R&D is tough.

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FDA Vas­cepa re­view spot­lights new safe­ty sig­nals, pos­si­ble min­er­al oil spoil­er as Amarin hunts a block­buster ap­proval

An in-house FDA review of Amarin’s Vascepa raises a set of hurdles the biotech will have to clear if the biotech expects to get the long-awaited FDA approval that could set it on a path to superstar status. But it appears that Amarin has survived another potential setback without introducing a major new threat to its prospects.

The stakes don’t get much higher, with analysts saying a win this week for Amarin could lead to billions in new sales — provided the agency stamps it with an OK. And investors liked what they say in the FDA review this morning, bumping the stock $AMRN 17%.

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FDA puts Sol­id Bio’s lead gene ther­a­py pro­gram on hold — again — af­ter an­oth­er pa­tient is hurt by SGT-001

Solid Biosciences continues to be plagued by safety issues.

Close to 18 months after the gene therapy biotech was able to quickly shed an FDA hold on their lead Duchenne muscular dystrophy program for SGT-001, regulators have stepped back in to force another halt after another patient was hit hard by a set of serious adverse events remarkably similar to the first set.

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FDA slaps a hold on an AML tri­al as Mark­er scraps a fail­ing ovar­i­an can­cer pro­gram, sink­ing shares

The FDA has placed a hold on a Phase II AML trial from the small immuno-oncology biotech Marker Therapeutics. Marker disclosed the issue two weeks after responding to FDA concerns, adding it to the Q3 release Tuesday. The company also announced it was scrapping a Phase II ovarian cancer program it determined was unlikely to succeed.

The agency’s concern centers around two reagents used in manufacturing for their trial for acute myeloid leukemia patients who have received a stem cell transplant. The reagents are from third parties and not present in the final product, Marker said.

Eli Lil­ly-backed biotech grabs $100M to dis­patch an­ti­body-oligonu­cleotide con­ju­gates af­ter mus­cu­lar dy­s­tro­phy

Hold up your hand. Make a fist. Now open it. And again.

If you can do it fully and with ease, then the proteins in your hand are likely working properly. If you can’t then they may not be. In people with myotonic muscular dystrophy, something more atomic is going on.

In those folks, the problem is RNA. Certain base pairs repeat far beyond normal, up to 11,000 superfluous letters in some cases. The extended strands form “clumps.” Proteins misform and can’t function properly. They often allow one movement but not the reverse, a condition called myotonia that gives the dystrophy its name.